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Understanding the Filaggrin Gene Mutation in Children with Eczema

Baby with eczema standing in crib sucking on pacifier

How the Filaggrin Gene Mutation Exacerbates Eczema

Eczema, or atopic dermatitis, is a common skin condition that causes dry, itchy, and inflamed patches on the skin. Recent studies have highlighted the role of the filaggrin gene in protecting the skin's barrier. Filaggrin is a crucial protein that helps maintain the skin’s hydration and integrity.

When there is a mutation in the filaggrin gene, it leads to a weakened skin barrier, making it more susceptible to irritants, allergens, and bacteria. This exacerbation is particularly prominent in children, whose skin is more delicate and reactive.

The Statistics Behind Filaggrin Gene Mutation and Eczema

Research reveals that approximately 10% of children with eczema have mutations in the filaggrin gene. This mutation significantly increases the risk and severity of eczema. The data underscores the necessity for targeted treatments and early intervention strategies to manage and possibly mitigate the impacts of this mutation.

Interestingly, filaggrin deficiency can also be present in children without a direct gene mutation. Environmental factors, such as harsh weather conditions or exposure to irritants, can reduce the production of filaggrin. As a result, these children still experience a compromised skin barrier and the associated challenges of managing eczema.

One of the most heart-wrenching manifestations of filaggrin deficiency is its impact on children’s cheeks. Because children's facial skin is extremely sensitive, a lack of filaggrin often results in pronounced eczema patches on the cheeks. These patches can be particularly itchy and painful, sometimes leading to secondary infections due to scratching and the delicate nature of the skin in this area.

Supplements to Combat Effects of Filaggrin Deficiency

While managing eczema requires a holistic approach, certain supplements have shown promise with helping to restore a compromised skin barrier.

  • Omega-3 Fatty Acids: Found in fish oil, omega-3 fatty acids have anti-inflammatory properties that can help reduce eczema flare-ups.

  • Vitamin D: Often deficient in children with eczema, vitamin D can help support immune function and reduce skin inflammation.

  • Probiotics: Beneficial for maintaining a healthy gut, which can influence skin health. Some strains like Lactobacillus rhamnosus GG have been shown to reduce eczema symptoms.

  • Zinc: This essential mineral helps in skin healing and inflammation control, potentially benefiting children with eczema.

  • Amino Acids: Certain amino acids, such as histidine, aid in the production of filaggrin. Incorporating protein-rich foods or supplements can assist in maintaining adequate levels of these amino acids.


Understanding the role of the filaggrin gene and the broader implications of filaggrin deficiency offers crucial insights into managing eczema in children. By recognizing the signs early and seeking appropriate care, including the use of beneficial supplements, parents and caregivers can significantly improve the quality of life for affected children. Awareness and education are key in providing the supportive and effective treatment these children deserve.

Schedule a Complimentary Consultation

If you’re looking for a holistic approach to treating eczema and finding the root cause, we’re here to help! Schedule a complimentary 15-minute consultation to learn more about our personalized treatments. We offer telehealth services in Arizona, New Mexico, and Colorado.

Take the first step towards a better quality of life for your child by scheduling your consultation today!

Disclaimer: The information provided in this blog post is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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